Glutaredoxin 2 antibody (AA 1-164)

Catalog No. ABIN7868229

The Rabbit Polyclonal anti-Glutaredoxin 2 antibody is suitable to detect Glutaredoxin 2 in samples from Human and Mouse. It has been validated for WB, ELISA, IHC (p) and IF.

Quick Overview for Glutaredoxin 2 antibody (AA 1-164) (ABIN7868229)

Target: Glutaredoxin 2 (GRX2)

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Glutaredoxin 2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Product Details anti-Glutaredoxin 2 Antibody

Binding Specificity: AA 1-164

Purpose: GLRX2 Antibody / Glutaredoxin 2

Purification: Affinity purified

Immunogen: A human recombinant partial protein (amino acids M1-Q164) was used as the immunogen for the GLRX2 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the GLRX2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the GLRX2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for Glutaredoxin 2

Target: Glutaredoxin 2 (GRX2)

Alternative Name: GLRX2

Background: GLRX2 (Glutaredoxin-2) also known as Glutaredoxin-2, mitochondrial or GRX2, is a protein that in humans is encoded by the GLRX2 gene. Glutaredoxins(e.g., GLRX) are a family of glutathione-dependent hydrogen donors that participate in a variety of cellular redox reactions. By sequence analysis, Lundberg et al.(2001) and Gladyshev et al.(2001) identified the GLRX2 gene within a clone mapping to chromosome 1q31.2-q31.3. Lundberg et al.(2001) determined that the GLRX2 gene contains 5 exons spanning about 9.6 kb. The GLRX2B transcript uses a first exon(exon 1B) located upstream from the first exon used by the GLRX2A transcript(exon 1A), suggesting that alternative splicing generates the isoforms. Lundberg et al.(2001)assayed reductase activity in recombinant proteins of both GLRX2 isoforms. They found that both have GSH-dependent dehydroascorbate reductase activity and 2-hydroxyethyl disulfide reductase activity.

UniProt: Q9NS18

Pathways: Cell RedoxHomeostasis