IL-31 antibody (AA 1-164)

Catalog No. ABIN7868231

This Mouse Monoclonal antibody specifically detects IL-31 in IHC (p). It exhibits reactivity toward Human.

Quick Overview for IL-31 antibody (AA 1-164) (ABIN7868231)

Target: IL-31 (IL31) (Interleukin 31 (IL31))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IL-31 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: IL31-7333

Product Details anti-IL-31 Antibody

Binding Specificity: AA 1-164

Purpose: Interleukin-31 Antibody / IL-31

Purification: Protein A/G affinity

Immunogen: A recombinant partial protein sequence (within amino acids 1-164) from the human protein was used as the immunogen for the Interleukin-31 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Interleukin-31 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Interleukin-31 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for IL-31

Target: IL-31 (IL31) (Interleukin 31 (IL31))

Alternative Name: Interleukin-31

Background: IL-31 is a T cell cytokine that is preferentially produced by T helper type 2 cells. IL-31 signals through a heterodimeric receptor composed of the IL-31 receptor (IL-31R) and the oncostatin M receptor (OSM). This receptor complex recruits JAK1, JAK2, Stat1, Stat3 and Stat5 signaling pathways, as well as the PI3 kinase/AKT cascade. SHP-2 and Shc adapter molecules are also recruited and contribute to an increased activation of the MAP kinase pathway in response to IL-31. Overexpression of IL-31 in mice results in pruritus and skin dermatitis resembling human atopic dermatitis (AD). Comparisons between skin from patients with AD and healthy skin showed IL-31R expression at higher levels on epidermal keratinocytes in AD samples. Infiltrating cells, more numerous in skin from patients with AD compared with that of healthy individuals, expressed IL-31 mRNA. IL-31 may participate in the cause of itch sensation and promote scratching behavior in NC/Nga mice with atopic dermatitis, and may represent a novel target for antipruritic drug development.

UniProt: Q6EBC2