Cofilin 2 antibody (AA 1-166)

Catalog No. ABIN7868232

The Mouse Monoclonal anti-Cofilin 2 antibody is suitable to detect Cofilin 2 in samples from Human. It has been validated for IHC (p).

Quick Overview for Cofilin 2 antibody (AA 1-166) (ABIN7868232)

Target: Cofilin 2 (CFL2)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Cofilin 2 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: CFL2-9963

Product Details anti-Cofilin 2 Antibody

Binding Specificity: AA 1-166

Purpose: Cofilin 2 Antibody / CFL2 (azide and preservative free)

Purification: Protein G affinity

Immunogen: A portion of amino acids 1-166 from human CFL2 protein was used as the immunogen for the Cofilin 2 antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the Cofilin 2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: -20 °C

Storage Comment: Aliquot the Cofilin 2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for Cofilin 2

Target: Cofilin 2 (CFL2)

Alternative Name: Cofilin 2

Background: Cofilin is ubiquitously expressed in eukaryotic cells where it binds to Actin, thereby regulating the rapid cycling of Actin assembly and disassembly essential for cellular viability. Cofilin is a low molecular weight protein that binds to filamentous (F) Actin by bridging two longitudinally associated Actin subunits changing the F-Actin filament twist. This process is allowed by the dephosphorylation of Cofilin Ser-3 by factors such as opsonized zymosan. Lim kinase 1, a serine kinase, phosphorylates Cofilin and renders it unable to bind and depolymerise F-Actin.

UniProt: Q9Y281

Pathways: Caspase Cascade in Apoptosis