Cofilin 2 antibody (AA 1-166)

Catalog No. ABIN7868233

The Mouse Monoclonal anti-Cofilin 2 antibody (Clone CFL2-9963) (ABIN7868233) specifically detects Cofilin 2 in IHC (p). The antibody is reactive with Human samples.

Quick Overview for Cofilin 2 antibody (AA 1-166) (ABIN7868233)

Target: Cofilin 2 (CFL2)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Cofilin 2 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: CFL2-9963

Product Details anti-Cofilin 2 Antibody

Binding Specificity: AA 1-166

Purpose: Cofilin 2 Antibody / CFL2

Purification: Protein G affinity

Immunogen: A portion of amino acids 1-166 from human CFL2 protein was used as the immunogen for the Cofilin 2 antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the Cofilin 2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Cofilin 2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for Cofilin 2

Target: Cofilin 2 (CFL2)

Alternative Name: Cofilin 2

Background: Cofilin is ubiquitously expressed in eukaryotic cells where it binds to Actin, thereby regulating the rapid cycling of Actin assembly and disassembly essential for cellular viability. Cofilin is a low molecular weight protein that binds to filamentous (F) Actin by bridging two longitudinally associated Actin subunits changing the F-Actin filament twist. This process is allowed by the dephosphorylation of Cofilin Ser-3 by factors such as opsonized zymosan. Lim kinase 1, a serine kinase, phosphorylates Cofilin and renders it unable to bind and depolymerise F-Actin.

UniProt: Q9Y281

Pathways: Caspase Cascade in Apoptosis