Centrin 1 antibody (AA 1-172)

Catalog No. ABIN7868245

The Mouse Monoclonal anti-Centrin 1 antibody (Clone CETN1-9878) (ABIN7868245) specifically detects Centrin 1 in IHC (p). The antibody is reactive with Human samples.

Quick Overview for Centrin 1 antibody (AA 1-172) (ABIN7868245)

Target: Centrin 1 (CETN1) (Centrin, EF-Hand Protein, 1 (CETN1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Centrin 1 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: CETN1-9878

Product Details anti-Centrin 1 Antibody

Binding Specificity: AA 1-172

Purpose: CETN1 Antibody / Centrin 1

Purification: Protein A/G affinity

Immunogen: A portion of amino acids 1-172 from human CETN1 protein was used as the immunogen for the CETN1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the CETN1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the CETN1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for Centrin 1

Target: Centrin 1 (CETN1) (Centrin, EF-Hand Protein, 1 (CETN1))

Alternative Name: CETN1

Background: EF-hand type Ca2+-binding proteins consists of several family members, including Centrin-1, Centrin-2 and Centrin-3. The Centrin proteins are ubiquitously expressed cytoskeletal components that show increased expression during cell differentiation. Tissues where cilia are present, such as the retina and testis, express both Centrin-1 and -2, but Centrin-2 is also expressed in nondifferentiated, nonciliated retinal cells (retinoblastoma cells), liver, skeletal muscle, and cardiac muscle. In these tissues, Centrin associates with the centrosomes, mitotic spindle poles, and basal bodies. Knockdown studies reveal a requirement for Centrin in centriole duplication and organization of spindle pole morphology and the completion of cytokinesis. Centrin-3 plays a role in centrosome reproduction.

UniProt: Q12798