CRYAA antibody (AA 1-173)

Catalog No. ABIN7868252

This Mouse Monoclonal antibody specifically detects CRYAA in WB and IF. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for CRYAA antibody (AA 1-173) (ABIN7868252)

Target: CRYAA (Crystallin, alpha A (CRYAA))

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This CRYAA antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Clone: 10B9

Product Details anti-CRYAA Antibody

Binding Specificity: AA 1-173

Purpose: CRYAA Antibody / Alpha A Crystallin

Purification: Antigen affinity purified

Immunogen: E. coli-derived recombinant human protein (amino acids M1-S173) was used as the immunogen for the CRYAA antibody.

Isotype: IgG1

Application Details

Application Notes: Optimal dilution of the CRYAA antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the CRYAA antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for CRYAA

Target: CRYAA (Crystallin, alpha A (CRYAA))

Alternative Name: CRYAA

Background: Alpha-crystallin A chain is a protein that in humans is encoded by the CRYAA gene. Mammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone, instead they hold them in large soluble aggregates. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alpha-A and alpha-B gene products are differentially expressed, alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Defects in this gene cause autosomal dominant congenital cataract (ADCC).

UniProt: P02489

Pathways: M Phase