CD3G antibody (AA 1-182)

Catalog No. ABIN7868270

This Mouse Monoclonal antibody specifically detects CD3G in IHC (p). It exhibits reactivity toward Human.

Quick Overview for CD3G antibody (AA 1-182) (ABIN7868270)

Target: CD3G (CD3g Molecule, gamma (CD3-TCR Complex) (CD3G))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD3G antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: CD3G-8794

Product Details anti-CD3G Antibody

Binding Specificity: AA 1-182

Purpose: CD3 gamma Antibody

Purification: Protein A/G affinity

Immunogen: A recombinant partial protein sequence (within amino acids 1-182) from the human protein was used as the immunogen for the CD3 gamma antibody.

Isotype: IgG2c, kappa

Application Details

Application Notes: Optimal dilution of the CD3 gamma antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the CD3 gamma antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for CD3G

Target: CD3G (CD3g Molecule, gamma (CD3-TCR Complex) (CD3G))

Alternative Name: CD3 gamma

Background: The T cell antigen receptor (TCR) recognizes foreign antigens and translates such recognition events into intracellular signals that elicit a change in the cell from a dormant to an activated state. Much of this signaling process can be attributed to a multisubunit complex of proteins that associates directly with the TCR. This complex has been designated CD3 (cluster of differentiation 3). It is composed of five invariant polypeptide chains that associate to form three dimers: a heterodimer of g and e chains (ge), a heterodimer of d and e chains (de) and a homodimer of two z chains (zz) or a heterodimer of z and h chains (zh). The z and h chains are encoded by the same gene but differ in their carboxyl-terminal ends due to an alternative splicing event. The g, e and d chains each contain a single copy of a conserved immunoreceptor tyrosinebased activation motif (ITAM). In contrast, the z chain contains three consecutive copies of the same motif. Phosphorylated ITAMs act as docking sites for protein kinases such as ZAP-70 and Syk and are also capable of regulating their kinase activity. The crystal structure of the ZAP-70 SH2 domains bound to the z chain ITAMs has been solved.

UniProt: P09693

Pathways: TCR Signaling, CXCR4-mediated Signaling Events