TTC36 antibody (AA 1-187)

Catalog No. ABIN7868325

The Rabbit Polyclonal anti-TTC36 antibody is suitable to detect TTC36 in samples from Human and Mouse. It has been validated for ELISA, FACS, ICC, IF and WB.

Quick Overview for TTC36 antibody (AA 1-187) (ABIN7868325)

Target: TTC36 (Tetratricopeptide Repeat Domain 36 (TTC36))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TTC36 antibody is un-conjugated

Application: ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB)

Product Details anti-TTC36 Antibody

Binding Specificity: AA 1-187

Purpose: TTC36 Antibody / Tetratricopeptide repeat protein 36

Purification: Immunogen affinity purified

Immunogen: E.coli-derived human TTC36 recombinant protein (Position: M1-D187) was used as the immunogen for the TTC36 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the TTC36 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the TTC36 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for TTC36

Target: TTC36 (Tetratricopeptide Repeat Domain 36 (TTC36))

Alternative Name: TTC36

Background: TTC36 antibody detects Tetratricopeptide repeat protein 36, a cytoplasmic protein containing multiple TPR motifs that mediate protein-protein interactions involved in cellular signaling and structural organization. The UniProt recommended name is Tetratricopeptide repeat protein 36 (TTC36). Although not fully characterized, TTC36 is believed to function as a molecular scaffold, facilitating the assembly of multiprotein complexes that regulate cell differentiation and signal transduction.

Functionally, TTC36 antibody identifies a 356-amino-acid protein rich in tetratricopeptide repeat sequences, which serve as recognition modules for chaperones and signaling enzymes. TTC36 interacts with cytoskeletal and membrane-associated proteins, suggesting roles in maintaining cell integrity and coordinating intracellular signaling. Its TPR domains likely promote conformational flexibility, enabling diverse binding partners.

The TTC36 gene is located on chromosome 6q22.33 and is expressed in epithelial tissues, gastrointestinal tract, and reproductive organs. Gene expression analyses indicate regulation by Wnt and TGF-beta pathways, implicating TTC36 in developmental and oncogenic signaling. Its expression in enterocytes and hepatocytes supports potential functions in nutrient transport or cellular adhesion.

Pathologically, altered TTC36 expression has been reported in several cancers, including hepatocellular carcinoma and gastric cancer, where its downregulation correlates with increased tumor growth and metastasis. TTC36 is thought to act as a tumor suppressor by modulating signaling cascades that control cell proliferation and adhesion. Research with TTC36 antibody aids in exploring these molecular interactions and their impact on cancer progression.

TTC36 antibody is suitable for western blotting, immunohistochemistry, and immunofluorescence to detect cytoplasmic TPR-containing scaffolds. NSJ Bioreagents offers TTC36 antibody reagents validated for studies of protein complex assembly, signaling regulation, and epithelial cell biology.

Structurally, TTC36 features tandem TPR motifs that create a solenoid-like architecture, enabling multipoint interactions with diverse proteins. This antibody supports detailed investigations into TTC36's scaffolding roles in intracellular communication and cancer biology.

UniProt: A6NLP5