VPRBP antibody (AA 1-195)
The Rabbit Polyclonal anti-VPRBP antibody (ABIN7868350) specifically detects VPRBP in ELISA, WB, FACS, IF and IHC (p).
The antibody is reactive with Human, Mouse and Rat samples.
Catalog No. ABIN7868350
$625.62
Plus shipping costs $50.00
100 μg
Shipping to:
United States
Delivery in 2 to 4 Business Days
Quick Overview for VPRBP antibody (AA 1-195) (ABIN7868350)
Target
See all VPRBP Antibodies
VPRBP
(Vpr (HIV-1) Binding Protein (VPRBP))
Reactivity
Human, Mouse, Rat
Host
Rabbit
Clonality
Polyclonal
Conjugate
This VPRBP antibody is un-conjugated
Application
ELISA, Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
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Binding Specificity
- AA 1-195
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Purpose
- VPRBP Antibody / DCAF1
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Purification
- Antigen affinity purified
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Immunogen
- Recombinant human protein (amino acids M1-R195) was used as the immunogen for the VPRBP antibody.
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Isotype
- IgG
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Application Notes
- Optimal dilution of the VPRBP antibody should be determined by the researcher.
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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Storage
- 4 °C,-20 °C
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Storage Comment
- After reconstitution, the VPRBP antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- VPRBP (Vpr (HIV-1) Binding Protein (VPRBP))
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Alternative Name
- VPRBP
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Target Type
- Viral Protein
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Background
- VprBP was first identified as a protein that can interact with HIV-1 viral protein R. It is a component of the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex that could interact with HIV-1 virus Vpr protein and HIV-2 virus Vpx protein. VprBP is a 1,507-amino acid protein that contains conserved domains, including YXXY repeats, the Lis homology motif, and WD40 repeats. Through binding to Vpr, VprBP allows Vpr to modulate the catalytic activity of the CUL4-DDB1 complex, which in turn leads to the induction of G2 phase arrest in the virus-infected cells. Recently it has been reported that VprBP is able to regulate the p53-induced transcription and apoptotic pathway.
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UniProt
- Q9Y4B6
Target
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