HSPB8 antibody (AA 1-196)

Catalog No. ABIN7868355

The Mouse Monoclonal anti-HSPB8 antibody is suitable to detect HSPB8 in samples from Human and Rat. It has been validated for WB, IF and FACS.

Quick Overview for HSPB8 antibody (AA 1-196) (ABIN7868355)

Target: HSPB8 (Heat Shock 22kDa Protein 8 (HSPB8))

Reactivity: Human, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This HSPB8 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)

Clone: 7D8

Product Details anti-HSPB8 Antibody

Binding Specificity: AA 1-196

Purpose: HSP22 Antibody / HSPB8

Purification: Affinity purified

Immunogen: Recombinant human protein (amino acids M1-T196) was used as the immunogen for the Hsp22 antibody.

Isotype: IgG2b

Application Details

Application Notes: Optimal dilution of the Hsp22 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Hsp22 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for HSPB8

Target: HSPB8 (Heat Shock 22kDa Protein 8 (HSPB8))

Alternative Name: HSP22

Background: Heat shock protein beta-8 is a protein that in humans is encoded by the HSPB8 gene. The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of this gene in induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, this gene appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease.

UniProt: Q9UJY1