Recombinant CNN1 antibody (AA 1-200)

Catalog No. ABIN7868395

The Mouse Monoclonal anti-CNN1 antibody (Clone rCNN1-9164) (ABIN7868395) specifically detects CNN1 in IHC (p). The antibody is reactive with Human samples.

Quick Overview for Recombinant CNN1 antibody (AA 1-200) (ABIN7868395)

Target: CNN1 (Calponin 1 (CNN1))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CNN1 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RCNN1-9164

Product Details anti-CNN1 Antibody

Binding Specificity: AA 1-200

Purpose: Recombinant CNN1 Antibody / Calponin-1

Purification: Protein A/G affinity

Immunogen: A recombinant fragment (within amino acids 1-200) of human CNN1 protein was used as the immunogen for the recombinant CNN1 antibody.

Isotype: IgG2b, kappa

Application Details

Application Notes: Optimal dilution of the recombinant CNN1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the recombinant CNN1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for CNN1

Target: CNN1 (Calponin 1 (CNN1))

Alternative Name: CNN1

Background: Multiple isoelectric variants of calponin have been identified, however only two molecular weight isoforms exist, a 34 kDa form and a 29 kDa form. Expression of the 29 kDa form, I-calponin, is primarily restricted to muscle of the urogenital tract, whereas the higher molecular weight variant has been demonstrated in vascular and visceral smooth muscle. In Western blotting, this MAb reacts with only the 34 kDa form of calponin in extracts of human aortic medial smooth muscle and is unreactive with fibroblast extracts of cultivated human foreskin. Calponin is a calmodulin, F-actin and tropomyosin binding protein, which is thought to be involved in the regulation of smooth muscle contraction. Calponin expression is restricted to smooth muscle cells and has been shown to be a marker of the differentiated (contractile) phenotype of developing smooth muscle.

UniProt: P51911