GCET2 antibody (AA 1-200)

Catalog No. ABIN7868493

The Mouse Monoclonal anti-GCET2 antibody is suitable to detect GCET2 in samples from Human. It has been validated for IHC (p).

Quick Overview for GCET2 antibody (AA 1-200) (ABIN7868493)

Target: GCET2 (Germinal Center Expressed Transcript 2 (GCET2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This GCET2 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: HGAL-830

Product Details anti-GCET2 Antibody

Binding Specificity: AA 1-200

Purpose: HGAL Antibody / GCSAM / GCET2

Purification: Protein A/G affinity

Immunogen: A portion of amino acids 1-200 was used as the immunogen for the HGAL antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the HGAL antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the HGAL antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for GCET2

Target: GCET2 (Germinal Center Expressed Transcript 2 (GCET2))

Alternative Name: HGAL

Background: Germinal center-associated signaling and motility protein / GCSAM, also called GCET2 and HGAL or hGAL, contains a putative PDZ-interacting domain, an immunoreceptor tyrosine-based activation motif (ITAM), and two putative SH2 binding sites. In B cells, its expression is specifically induced by interleukin-4. HGAL is specifically expressed in germinal center B-cells, but is absent in mantle and marginal zone B-cells and in the inter-follicular and para-cortical regions in normal tonsils and lymph nodes. Its high degree of specificity for germinal center B-cells makes anti-HGAL an ideal marker for the detection of germinal center-derived B-cell lymphomas. HGAL expression has been used to help elucidate nodal marginal zone lymphoma (NMZL) from cases of diffuse follicle center lymphoma. Additionally, HGAL expression was shown to correlate with survival in patients with diffuse large B-cell lymphoma (DLBCL).

UniProt: Q8N6F7