IL18R1 antibody (AA 1-200)

Catalog No. ABIN7868579

This Mouse Monoclonal antibody specifically detects IL18R1 in IHC (p). It exhibits reactivity toward Human.

Quick Overview for IL18R1 antibody (AA 1-200) (ABIN7868579)

Target: IL18R1 (Interleukin 18 Receptor 1 (IL18R1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IL18R1 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: IL18R1-7593

Product Details anti-IL18R1 Antibody

Binding Specificity: AA 1-200

Purpose: IL-18R alpha Antibody / IL18R1

Purification: Protein A/G affinity

Immunogen: A recombinant partial protein sequence (within amino acids 1-200) from the human protein was used as the immunogen for the IL-18R alpha antibody.

Isotype: IgG2, kappa

Application Details

Application Notes: Optimal dilution of the IL-18R alpha antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the IL-18R alpha antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for IL18R1

Target: IL18R1 (Interleukin 18 Receptor 1 (IL18R1))

Alternative Name: IL-18R alpha

Background: Interleukin-18 (IL-18) has been identified as a molecule that induces IFN-Gamma production and enhances NK cell cytotoxicity. IL-18 receptor (IL-18R) is a type I membrane protein present in lung, leukocytes, spleen, liver, thymus, prostate, small intestine, colon, placenta and heart, and absent from brain, skeletal muscle, pancreas and kidney. IL-18R is present in Hodgkin s disease cell lines, and does not bind IL-1Alpha or IL-1beta. The association of IL-18 to IL-18R leads to activation of NFkB. At present two subunits of IL-18R have been characterized: IL-18RAlpha and IL-18Rbeta. IL-18RAlpha has been described as the ligand-binding chain and IL-18Rbeta as the signal-transduction chain.

UniProt: Q13478