IL20RA antibody (AA 1-200)

Catalog No. ABIN7868585

This Mouse Monoclonal antibody specifically detects IL20RA in IHC (p). It exhibits reactivity toward Human.

Quick Overview for IL20RA antibody (AA 1-200) (ABIN7868585)

Target: IL20RA (Interleukin 20 Receptor alpha (IL20RA))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IL20RA antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: IL20RA-1752

Product Details anti-IL20RA Antibody

Binding Specificity: AA 1-200

Purpose: IL20R alpha Antibody / IL-20 receptor subunit alpha

Purification: Protein A/G affinity

Immunogen: A recombinant partial protein sequence (within amino acids 1-200) from the human protein was used as the immunogen for the IL20R alpha antibody.

Isotype: IgG2, kappa

Application Details

Application Notes: Optimal dilution of the IL20R alpha antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the IL20R alpha antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for IL20RA

Target: IL20RA (Interleukin 20 Receptor alpha (IL20RA))

Alternative Name: IL20R alpha

Background: The class II cytokine receptor family includes 12 members, 11 of which combine as various heterodimers to transduce signals across the cellular membrane for 27 cytokines. These cytokines are divided into four structurally related groups: six cytokines of the IL-10 family, 17 type I IFNs, one type II IFN and three IFN-l. IL-20 is a member of the IL-10 family of cytokines that has been shown to be upregulated in psoriatic skin. The receptor for IL-20 (IL-20R) exists as a dimer consisting of IL-20Ra and IL-20Rb. IL-20R also functions as a receptor for IL-19, IL-24 and IL-26. It is highly expressed in skin, brain and testis. IL-20, IL-20Ra and IL-20Rb all have higher expression levels in psoriatic lesional (LS) skin than in nonlesional (NL) skin, suggesting a role for these proteins as potential therapeutic targets. IL-20 can induce signal transducer and activator of transcription (Stat) activation through IL-20R.

UniProt: Q9UHF4