IL22RA2 antibody (AA 1-200)

Catalog No. ABIN7868589

The Mouse Monoclonal anti-IL22RA2 antibody is suitable to detect IL22RA2 in samples from Human. It has been validated for IHC (p).

Quick Overview for IL22RA2 antibody (AA 1-200) (ABIN7868589)

Target: IL22RA2 (Interleukin 22 Receptor, alpha 2 (IL22RA2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IL22RA2 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: IL22RA2-7291

Product Details anti-IL22RA2 Antibody

Binding Specificity: AA 1-200

Purpose: IL22RA2 Antibody / Interleukin-22 receptor subunit alpha 2

Purification: Protein A/G affinity

Immunogen: A recombinant partial protein sequence (within amino acids 1-200) from the human protein was used as the immunogen for the IL22RA2 antibody.

Isotype: IgG2, kappa

Application Details

Application Notes: Optimal dilution of the IL22RA2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the IL22RA2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for IL22RA2

Target: IL22RA2 (Interleukin 22 Receptor, alpha 2 (IL22RA2))

Alternative Name: IL22RA2

Background: IL-22RAlpha2 (Interleukin-22 receptor Alpha2 chain), also known as IL-22 binding protein (IL-22BP), cytokine receptor family class II member 10 (CRF2-10) or CRF2- soluble 1 (CRF2-S1), is a soluble, nonsignaling single chain receptor for IL-22. It is highly expressed in intestine and lymph nodes and is also found in spleen, kidney and liver. IL-22RAlpha2 has a cytokine-binding domain that contains two FnIII domains. Its affinity for IL-22 is 4- to 10-fold higher than that of the membrane-bound IL-22 receptor, however it has a dissociation rate up to 20 times lower. By binding to IL-22, IL-22RAlpha2 prevents the binding to the IL-22 membrane-bound receptor and therefore inhibits IL-22 signaling. This suggests that IL-22RAlpha2 may be important in regulating inflammatory responses. In addition, IL-22RAlpha2 can be induced by lipopolysaccharides (LPSs).

UniProt: Q969J5