HAND2 antibody (AA 1-208)

Catalog No. ABIN7868818

The Rabbit Polyclonal anti-HAND2 antibody (ABIN7868818) specifically detects HAND2 in IHC (p). The antibody is reactive with Zebrafish (Danio rerio) samples.

Quick Overview for HAND2 antibody (AA 1-208) (ABIN7868818)

Target: HAND2 (Heart and Neural Crest Derivatives Expressed 2 (HAND2))

Reactivity: Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HAND2 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-HAND2 Antibody

Binding Specificity: AA 1-208

Purpose: Zebrafish Hand2 Antibody / Heart and neural crest derivatives expressed 2

Purification: Antigen affinity chromatography

Immunogen: E. coli-derived zebrafish Hand2 recombinant protein (amino acids M1-Q208) was used as the immunogen for the Zebrafish Hand2 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Optimal dilution of the Zebrafish Hand2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Zebrafish Hand2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for HAND2

Target: HAND2 (Heart and Neural Crest Derivatives Expressed 2 (HAND2))

Alternative Name: Hand2

Background: Hand2, or heart and neural crest derivatives expressed two, is a basic helix loop helix transcription factor that plays a vital role in the development of the heart, limbs, and neural crest derived tissues. In zebrafish, Hand2 is essential for proper cardiac morphogenesis, vascular development, and craniofacial patterning.

During early zebrafish embryogenesis, Hand2 is expressed in the lateral plate mesoderm and contributes to the specification and differentiation of cardiac progenitor cells. It is particularly important for the formation of the heart tube and for the development of the atrial and ventricular chambers. Hand2 also regulates the migration and function of neural crest cells, which give rise to structures such as the jaw and pharyngeal arches.

Loss of Hand2 function in zebrafish leads to severe defects in heart formation, including impaired looping and chamber development, as well as abnormalities in craniofacial structures. Because of its conserved role in vertebrate development, zebrafish Hand2 is widely used as a model for studying congenital heart defects, craniofacial malformations, and the genetic pathways that guide mesodermal and neural crest cell differentiation.

Zebrafish Hand2 is a valuable tool in developmental biology, regenerative medicine, and disease modeling, particularly in research focused on cardiac development and structural birth defects.

UniProt: P57102

Pathways: Tube Formation, Feeding Behaviour