MSRA antibody (AA 1-215)

Catalog No. ABIN7868832

The Rabbit Polyclonal anti-MSRA antibody is suitable to detect MSRA in samples from Human, Mouse and Rat. It has been validated for WB, ELISA and FACS.

Quick Overview for MSRA antibody (AA 1-215) (ABIN7868832)

Target: MSRA (Methionine Sulfoxide Reductase A (MSRA))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MSRA antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Product Details anti-MSRA Antibody

Binding Specificity: AA 1-215

Purpose: MSRA Antibody / Methionine sulfoxide reductase A

Purification: Immunogen affinity purified

Immunogen: E.coli-derived mouse MSRA recombinant protein (Position: M1-D215) was used as the immunogen for the MSRA antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the MSRA antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the MSRA antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for MSRA

Target: MSRA (Methionine Sulfoxide Reductase A (MSRA))

Alternative Name: MSRA

Background: MSRA antibody detects Methionine sulfoxide reductase A, a key antioxidant enzyme that repairs oxidized methionine residues in proteins, restoring their function and protecting cells from oxidative stress. Encoded by the MSRA gene on chromosome 8p23.1, this enzyme belongs to the methionine sulfoxide reductase family and plays an essential role in maintaining protein integrity and cellular redox balance. By catalyzing the reduction of methionine-S-sulfoxide back to methionine, MSRA reverses oxidative damage caused by reactive oxygen species (ROS).

Structurally, MSRA is a 235-amino-acid protein of approximately 26 kilodaltons containing a thioredoxin-like catalytic domain with a conserved cysteine residue essential for redox cycling. It exists in multiple isoforms localized to cytosolic, mitochondrial, and peroxisomal compartments, ensuring broad cellular protection. The enzyme utilizes thioredoxin as an electron donor, enabling reduction of oxidized methionine residues in structural and metabolic proteins.

The MSRA antibody is widely used in oxidative stress, neurodegeneration, and aging research to study redox regulation, protein repair, and cellular stress defense. Western blot analysis detects a 26 kilodalton band corresponding to MSRA, while immunofluorescence shows strong cytoplasmic and mitochondrial staining. This antibody provides a powerful tool for analyzing antioxidant defense systems and understanding how methionine oxidation influences cellular resilience and disease processes.

Functionally, MSRA contributes to cellular longevity by maintaining the functionality of oxidatively damaged proteins, particularly in mitochondria where ROS production is high. It has been implicated in protecting against neurodegenerative disorders, cardiovascular diseases, and metabolic stress. Loss of MSRA activity accelerates protein oxidation and mitochondrial dysfunction, whereas its overexpression enhances stress tolerance and lifespan in model organisms. The MSRA antibody supports research into oxidative repair mechanisms, antioxidant therapeutics, and the molecular basis of redox regulation. NSJ Bioreagents validates this antibody for its applications, ensuring accuracy in studies of protein oxidation and repair.

UniProt: Q9D6Y7