Phospholamban antibody (AA 1-23)

Catalog No. ABIN7868877

The Rabbit Polyclonal anti-Phospholamban antibody is suitable to detect Phospholamban in samples from Human, Rat and Mouse. It has been validated for WB and ELISA.

Quick Overview for Phospholamban antibody (AA 1-23) (ABIN7868877)

Target: Phospholamban (PLN)

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Phospholamban antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Phospholamban Antibody

Binding Specificity: AA 1-23

Purpose: Cardiac Phospholamban Antibody / PLN / PLB

Purification: Antigen affinity purified

Immunogen: E. coli-derived recombinant human protein (amino acids M1-Q23) was used as the immunogen for the Cardiac Phospholamban antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Cardiac Phospholamban antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Cardiac Phospholamban antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for Phospholamban

Target: Phospholamban (PLN)

Alternative Name: Cardiac Phospholamban

Background: Phospholamban is a 52 amino acid integral membrane protein that regulates the Ca2+ pump in cardiac muscle and skeletal muscle cells. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. Phospholamban is also expressed in slow-twitch skeletal muscle and some smooth muscle cells. It is observed that human ventricle and quadriceps displayed high levels of phospholamban transcripts and proteins, with markedly lower expression observed in smooth muscles, while the right atrium also expressed low levels of phospholamban. The structure of the human phospholamban gene closely resembles that reported for chicken, rabbit, rat, and mouse. Comparison of the human to other mammalian phospholamban genes indicated a marked conservation of sequence for at least 217 bp upstream of the transcription start site.

UniProt: P26678

Pathways: Negative Regulation of Transporter Activity