GTPase, IMAP Family Member 1 (GIMAP1) (AA 1-238) antibody

Catalog No. ABIN7868892

The Rabbit Polyclonal anti-GTPase, IMAP Family Member 1 antibody is suitable to detect GTPase, IMAP Family Member 1 in samples from Human. It has been validated for WB, ELISA and FACS.

Quick Overview for GTPase, IMAP Family Member 1 (GIMAP1) (AA 1-238) antibody (ABIN7868892)

Target: GTPase, IMAP Family Member 1 (GIMAP1)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Product Details

Binding Specificity: AA 1-238

Purpose: GIMAP1 Antibody / GTPase IMAP family member 1

Purification: Immunogen affinity purified

Immunogen: E.coli-derived human GIMAP1 recombinant protein (Position: M1-E238) was used as the immunogen for the GIMAP1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the GIMAP1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the GIMAP1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details

Target: GTPase, IMAP Family Member 1 (GIMAP1)

Alternative Name: GIMAP1

Background: GIMAP1 antibody detects GTPase IMAP family member 1, a small GTP-binding protein involved in lymphocyte survival and immune regulation. The UniProt recommended name is GTPase IMAP family member 1 (GIMAP1). This protein belongs to the GIMAP (GTPase of immunity-associated proteins) family, which participates in T-cell development, apoptosis resistance, and mitochondrial homeostasis within immune cells.

Functionally, GIMAP1 antibody identifies a 320-amino-acid cytoplasmic and mitochondrial membrane-associated GTPase. GIMAP1 regulates cell survival by maintaining mitochondrial integrity and preventing apoptotic signaling during lymphocyte maturation. It interacts with other GIMAP family members and BCL2-related proteins to modulate intrinsic apoptosis pathways. GIMAP1 expression is induced during T-cell activation and may help coordinate metabolic adaptation and survival under stress conditions.

The GIMAP1 gene is located on chromosome 7q36.1 and is expressed predominantly in thymus, spleen, and peripheral lymphocytes. Its expression pattern mirrors that of immune cell differentiation markers, underscoring its role in adaptive immunity. GIMAP1 acts as a key survival regulator in the transition of T-cells from double-positive to single-positive stages in the thymus.

Pathologically, GIMAP1 dysregulation has been linked to autoimmune disorders and lymphoid malignancies. Loss of function leads to increased apoptosis of lymphocytes and immunodeficiency, while overexpression contributes to T-cell survival in leukemia. Research using GIMAP1 antibody supports studies in immunology, cell survival pathways, and mitochondrial regulation in immune cells.

GIMAP1 antibody is validated for western blotting, immunofluorescence, and flow cytometry to detect small GTPases involved in immune cell regulation. NSJ Bioreagents provides GIMAP1 antibody reagents optimized for research in lymphocyte biology, apoptosis resistance, and mitochondrial signaling.

Structurally, GTPase IMAP family member 1 contains conserved GTP-binding motifs typical of small GTPases, including the P-loop, switch I, and switch II regions that mediate nucleotide binding and hydrolysis. Its membrane association and GTP-dependent conformational changes regulate interactions with mitochondrial and cytoskeletal components. This antibody enables detailed analysis of GIMAP1's role in immune homeostasis and cell survival signaling.

UniProt: Q8WWP7