GIMAP5 antibody (AA 1-240)

Catalog No. ABIN7868904

The Rabbit Polyclonal anti-GIMAP5 antibody is suitable to detect GIMAP5 in samples from Human. It has been validated for WB and ELISA.

Quick Overview for GIMAP5 antibody (AA 1-240) (ABIN7868904)

Target: GIMAP5 (GTPase, IMAP Family Member 5 (GIMAP5))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GIMAP5 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-GIMAP5 Antibody

Binding Specificity: AA 1-240

Purpose: GIMAP5 Antibody / GTPase IMAP family member 5

Purification: Immunogen affinity purified

Immunogen: E.coli-derived human GIMAP5 recombinant protein (Position: M1-E240) was used as the immunogen for the GIMAP5 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the GIMAP5 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the GIMAP5 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for GIMAP5

Target: GIMAP5 (GTPase, IMAP Family Member 5 (GIMAP5))

Alternative Name: GIMAP5

Background: GIMAP5 antibody detects GTPase IMAP family member 5, encoded by the GIMAP5 gene. GTPase IMAP family member 5 is a small GTP-binding protein involved in lymphocyte survival, immune regulation, and autoimmunity. GIMAP5 antibody provides researchers with a specific reagent for studying T cell homeostasis, immune tolerance, and lymphocyte biology.

GTPase IMAP family member 5 belongs to the GIMAP family of immune-associated GTPases. Research using GIMAP5 antibody has shown that it is expressed in T cells, natural killer cells, and other lymphoid lineages. It regulates mitochondrial integrity and apoptosis pathways, promoting lymphocyte survival during development and immune responses.

Studies with GIMAP5 antibody have revealed that mutations in GIMAP5 cause lymphopenia and autoimmunity in rat models. In humans, variants in GIMAP5 have been linked to systemic lupus erythematosus, type 1 diabetes, and other autoimmune disorders. These findings demonstrate the importance of GIMAP5 in maintaining immune tolerance and homeostasis.

Dysregulation of GTPase IMAP family member 5 has also been associated with altered T cell signaling and chronic inflammation. Research using GIMAP5 antibody has shown that deficiency impairs mitochondrial stability and increases susceptibility to apoptosis, leading to reduced T cell numbers and immune dysregulation.

GIMAP5 antibody is widely applied in flow cytometry, western blotting, and immunohistochemistry. Flow cytometry identifies lymphocyte subsets expressing GIMAP5, western blotting quantifies protein levels, and immunohistochemistry demonstrates tissue distribution in lymphoid organs. These applications make GIMAP5 antibody indispensable for immunology research.

By providing validated GIMAP5 antibody reagents, NSJ Bioreagents supports studies into T cell survival, autoimmune disease, and immune regulation. Detection of GTPase IMAP family member 5 provides researchers with insight into how immune-associated GTPases regulate lymphocyte biology and tolerance.

UniProt: Q96F15

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response