HMMR antibody (AA 1-250)

Catalog No. ABIN7868944

The Mouse Monoclonal anti-HMMR antibody (Clone HMMR-8021) (ABIN7868944) specifically detects HMMR in IHC (p). The antibody is reactive with Human samples.

Quick Overview for HMMR antibody (AA 1-250) (ABIN7868944)

Target: HMMR (Hyaluronan-Mediated Motility Receptor (RHAMM) (HMMR))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This HMMR antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: HMMR-8021

Product Details anti-HMMR Antibody

Binding Specificity: AA 1-250

Purpose: CD168 Antibody / HMMR

Purification: Protein A/G affinity

Immunogen: A recombinant partial protein sequence (within amino acids 1-250) from the human protein was used as the immunogen for the CD168 antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the CD168 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the CD168 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for HMMR

Target: HMMR (Hyaluronan-Mediated Motility Receptor (RHAMM) (HMMR))

Alternative Name: CD168

Background: Hyaluronic acid (HA) is a nonsulfated glycosaminoglycan that regulates cell adhesion and migration. HA effects are mediated through two receptors, CD44 (also designated HCAM) and the receptor of hyaluronic acid mediated motility (RHAMM). RHAMM, also designated intracellular hyaluronic acid binding protein (IHABP) and CD168, is a matrix receptor, which is linked to the plasma membrane by a GPI anchor and regulates cell motility. RHAMM expression is upregulated in malignant lymphoid tissues and is subsequently implicated in tumor progression and metastasis formation, as well as signal transduction. Although still unclear, RHAMM is thought to exist as several isoforms ranging in size. A variant isoform, designated v4, is a protein that when over-expressed, is thought to be the cause of transformation and metastasis formation in fibroblasts.

UniProt: O75330

Pathways: Glycosaminoglycan Metabolic Process