Synaptoporin antibody (AA 1-265)

Catalog No. ABIN7869003

The Rabbit Polyclonal anti-Synaptoporin antibody is suitable to detect Synaptoporin in samples from Human, Rat and Mouse. It has been validated for WB, ELISA, FACS and IHC.

Quick Overview for Synaptoporin antibody (AA 1-265) (ABIN7869003)

Target: Synaptoporin (SYNPR)

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Synaptoporin antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (IHC)

Product Details anti-Synaptoporin Antibody

Binding Specificity: AA 1-265

Purpose: SYNPR Antibody / Synaptoporin

Purification: Immunogen affinity purified

Immunogen: E.coli-derived human Synaptoporin/SYNPR recombinant protein (Position: M1-I265) was used as the immunogen for the SYNPR antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the SYNPR antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the SYNPR antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for Synaptoporin

Target: Synaptoporin (SYNPR)

Alternative Name: SYNPR

Background: SYNPR antibody detects Synaptoporin, encoded by the SYNPR gene. Synaptoporin is a synaptic vesicle protein belonging to the synaptophysin family and is highly enriched in hippocampal mossy fiber terminals. SYNPR antibody provides researchers with a specific reagent to study synaptic vesicle biology, neurotransmission, and neural circuit regulation.

Synaptoporin is a small integral membrane protein that shares structural similarity with synaptophysin but has distinct expression patterns. Research using SYNPR antibody has shown that Synaptoporin localizes to presynaptic vesicles, where it contributes to vesicle cycling and exocytosis. Its enrichment in specific hippocampal circuits highlights its specialized role in regulating excitatory neurotransmission.

Studies with SYNPR antibody have revealed that Synaptoporin is particularly abundant in mossy fiber terminals of granule cells projecting to CA3 pyramidal neurons. This selective localization has made SYNPR a useful marker for hippocampal circuitry studies. Its presence supports efficient vesicle recycling, ensuring sustained neurotransmitter release during high-frequency stimulation.

Synaptoporin has also been implicated in synaptic plasticity. Research using SYNPR antibody has demonstrated that altered expression or distribution of Synaptoporin correlates with changes in long-term potentiation and synaptic remodeling. This suggests that Synaptoporin contributes to the molecular basis of learning and memory by supporting plastic synaptic responses.

Dysregulation of Synaptoporin is associated with neurological disease. Studies with SYNPR antibody have linked altered expression to epilepsy and neurodegenerative disorders, where synaptic dysfunction is a hallmark. These associations emphasize the relevance of SYNPR to both basic neuroscience and pathology.

SYNPR antibody is widely used in immunohistochemistry, immunofluorescence, and western blotting. Immunohistochemistry highlights localization in hippocampal circuits, immunofluorescence reveals colocalization with synaptic vesicle markers, and western blotting quantifies protein levels in neuronal tissue. These applications make SYNPR antibody indispensable for neuroscience research.

By supplying validated SYNPR antibody reagents, NSJ Bioreagents supports studies into synaptic vesicle biology, hippocampal circuitry, and neurological disease. Detection of Synaptoporin provides researchers with insight into how specialized synaptic proteins regulate neurotransmission and plasticity.

UniProt: Q8TBG9