ANAPC5 antibody (AA 1-266)

Catalog No. ABIN7869004

The Rabbit Polyclonal anti-ANAPC5 antibody (ABIN7869004) specifically detects ANAPC5 in WB, ELISA, FACS and IF. The antibody is reactive with Human samples.

Quick Overview for ANAPC5 antibody (AA 1-266) (ABIN7869004)

Target: ANAPC5 (Anaphase Promoting Complex Subunit 5 (ANAPC5))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ANAPC5 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (IF)

Product Details anti-ANAPC5 Antibody

Binding Specificity: AA 1-266

Purpose: Apc5 Antibody / Anaphase-promoting complex subunit 5

Purification: Affinity purified

Immunogen: A human recombinant partial protein (amino acids M1-D266) was used as the immunogen for the Apc5 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Apc5 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Apc5 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for ANAPC5

Target: ANAPC5 (Anaphase Promoting Complex Subunit 5 (ANAPC5))

Alternative Name: Apc5

Background: Anaphase-promoting complex subunit 5 is an enzyme that in humans is encoded by the ANAPC5 gene. This gene encodes a tetratricopeptide repeat-containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for the proper ubiquitination function of APC/C and for the interaction of APC/C with transcription coactivators. It also interacts with polyA binding protein and represses internal ribosome entry site-mediated translation. Multiple transcript variants encoding different isoforms have been found for this gene. These differences cause translation initiation at a downstream AUG and result in a shorter protein (isoform b), compared to isoform a.

UniProt: Q9UJX4

Pathways: M Phase