KCNIP2 antibody (AA 1-270)

Catalog No. ABIN7869016

The Mouse Monoclonal anti-KCNIP2 antibody (Clone KCNIP2-7588) (ABIN7869016) specifically detects KCNIP2 in IHC (p). The antibody is reactive with Human samples.

Quick Overview for KCNIP2 antibody (AA 1-270) (ABIN7869016)

Target: KCNIP2 (Kv Channel Interacting Protein 2 (KCNIP2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This KCNIP2 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: KCNIP2-7588

Product Details anti-KCNIP2 Antibody

Binding Specificity: AA 1-270

Purpose: KCNIP2 Antibody / KChIP2

Purification: Protein A/G affinity

Immunogen: A recombinant partial protein (within amino acids 1-270) from the human protein was used as the immunogen for the KCNIP2 antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the KCNIP2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the KCNIP2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for KCNIP2

Target: KCNIP2 (Kv Channel Interacting Protein 2 (KCNIP2))

Alternative Name: KCNIP2

Background: In the brain and heart, rapidly inactivating (A-type) voltage-gated potassium (Kv) currents control the excitability of neurons and cardiac myocytes. KChIPs are Kv channel-interacting proteins that bind to the cytoplasmic amino termini of Kv4Alpha-subunits and are integral components of native Kv4 channel complexes. KChIP family members include KChIP1 expressed in brain, KChIP2 (KCNIP2) expressed in heart, brain, and lung, and KChIP3 (previously identified as calsenilin) expressed in brain and testis. In rat brain, KChIP1 colocalizes with Kv4.3 in granule cells and KChIP2 colocalizes with Kv4.2 in both neocoritcal and subcortical structures. The KChIPs are members of the recoverin/neuronal calcium sensor-1 subfamily of calcium-binding proteins and show 99 % nucleotide homology to DREAM, suggesting that KChIPs may have activity beyond modulation of Kv4 channels.

UniProt: Q9NS61