AFT1 antibody (AA 1-271)

Catalog No. ABIN7869020

This Mouse Monoclonal antibody specifically detects AFT1 in WB, IF, IHC (p) and FACS. It exhibits reactivity toward Human.

Quick Overview for AFT1 antibody (AA 1-271) (ABIN7869020)

Target: AFT1 (Activating Transcription Factor 1 (AFT1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This AFT1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Clone: 7F8

Product Details anti-AFT1 Antibody

Binding Specificity: AA 1-271

Purpose: ATF1 Antibody

Purification: Affinity purified

Immunogen: Recombinant human protein (amino acids M1-V271) was used as the immunogen for the ATF1 antibody.

Isotype: IgG2a

Application Details

Application Notes: Optimal dilution of the ATF1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the ATF1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for AFT1

Target: AFT1 (Activating Transcription Factor 1 (AFT1))

Alternative Name: ATF1

Background: ATF1, also known as activating transcription factor 1, is a protein that in humans is encoded by the ATF1 gene. It is mapped to 12q13.12. This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation.

UniProt: P18846

Pathways: Neurotrophin Signaling Pathway, Activation of Innate immune Response, Myometrial Relaxation and Contraction, Toll-Like Receptors Cascades