SESN1 antibody (AA 1-275)

Catalog No. ABIN7869032

This Rabbit Polyclonal antibody specifically detects SESN1 in WB, ELISA, FACS and IF. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for SESN1 antibody (AA 1-275) (ABIN7869032)

Target: SESN1 (Sestrin 1 (SESN1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SESN1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (IF)

Product Details anti-SESN1 Antibody

Binding Specificity: AA 1-275

Purpose: PA26 Antibody / SESN1 / SEST1 / Sestrin 1

Purification: Antigen affinity purified

Immunogen: E. coli-derived recombinant human protein (amino acids M1-A275) was used as the immunogen for the PA26 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the PA26 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the PA26 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for SESN1

Target: SESN1 (Sestrin 1 (SESN1))

Alternative Name: PA26

Background: Sestrin 1, also known as p53-regulated protein PA26 and SEST1, is a protein that in humans is encoded by the SESN1 gene. This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

UniProt: Q9Y6P5