CrkL antibody (AA 1-292)

Catalog No. ABIN7869062

This Rabbit Polyclonal antibody specifically detects CrkL in WB, IF and IHC (p). It exhibits reactivity toward Zebrafish (Danio rerio).

Quick Overview for CrkL antibody (AA 1-292) (ABIN7869062)

Target: CrkL (CRKL) (V-Crk Sarcoma Virus CT10 Oncogene Homolog (Avian)-Like (CRKL))

Reactivity: Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CrkL antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-CrkL Antibody

Binding Specificity: AA 1-292

Purpose: Zebrafish CrkL Antibody / Crk-like protein

Purification: Antigen affinity chromatography

Immunogen: An E.coli-derived zebrafish CrkL recombinant protein (amino acids M1-H292) was used as the immunogen for the Zebrafish CrkL antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Optimal dilution of the Zebrafish CrkL antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Zebrafish CrkL antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for CrkL

Target: CrkL (CRKL) (V-Crk Sarcoma Virus CT10 Oncogene Homolog (Avian)-Like (CRKL))

Alternative Name: CrkL

Background: Crk-like protein is a protein that in humans is encoded by the CRKL gene. This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.

UniProt: Q6PH06

Pathways: Interferon-gamma Pathway, Neurotrophin Signaling Pathway, Signaling of Hepatocyte Growth Factor Receptor