FOXD1 antibody (AA 1-30)

Catalog No. ABIN7869089

This Rabbit Polyclonal antibody specifically detects FOXD1 in WB, IHC (p) and IF. It exhibits reactivity toward Human and Mouse.

Quick Overview for FOXD1 antibody (AA 1-30) (ABIN7869089)

Target: FOXD1 (Forkhead Box D1 (FOXD1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FOXD1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Product Details anti-FOXD1 Antibody

Binding Specificity: AA 1-30

Purpose: FOXD1 Antibody / Forkhead box protein D1

Purification: Antigen affinity

Immunogen: A portion of amino acids 1-30 from the human protein was used as the immunogen for the FOXD1 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: The stated application concentrations are suggested starting points. Titration of the FOXD1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the FOXD1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for FOXD1

Target: FOXD1 (Forkhead Box D1 (FOXD1))

Alternative Name: FOXD1

Background: FOXD1 belongs to the forkhead box protein family, specifically the forkhead box D (FOX D) subfamily. It is involved in regulating gene expression by binding to specific DNA sequences and influencing transcription. FOXD1 is known to play essential roles in embryonic development, particularly in the formation of various tissues and organs. In addition, it has been implicated in the regulation of cell proliferation, differentiation, and survival. It is also involved in the development of the kidney and nervous system. Studies have shown that FOXD1 is essential for the formation of the metanephric mesenchyme, a precursor structure for the kidney. Moreover, FOXD1 has been linked to neurogenesis and neuronal differentiation, highlighting its crucial role in brain development. Dysregulation of FOXD1 expression has been associated with several diseases and disorders. For instance, aberrant expression of FOXD1 has been observed in various cancers, including breast cancer, lung cancer, and renal cell carcinoma. In these contexts, FOXD1 may act as an oncogene or tumor suppressor, depending on the cellular context and signaling pathways involved. Furthermore, FOXD1 has been implicated in the pathogenesis of neurodevelopmental disorders, such as autism and schizophrenia. Studies have suggested that dysregulated FOXD1 expression may contribute to the atypical brain development seen in these conditions.

UniProt: Q16676