ETV4 antibody (AA 1-333)

Catalog No. ABIN7869205

The Rabbit Polyclonal anti-ETV4 antibody (ABIN7869205) specifically detects ETV4 in WB. The antibody is reactive with Zebrafish (Danio rerio) samples.

Quick Overview for ETV4 antibody (AA 1-333) (ABIN7869205)

Target: ETV4 (Ets Variant 4 (ETV4))

Reactivity: Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ETV4 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ETV4 Antibody

Binding Specificity: AA 1-333

Purpose: Zebrafish Etv4 Antibody / ETS translocation variant 4 / Pea3

Purification: Antigen affinity chromatography

Immunogen: E. coli-derived zebrafish Etv4 recombinant protein (amino acids M1-E333) was used as the immunogen for the Zebrafish Etv4 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Optimal dilution of the Zebrafish Etv4 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Zebrafish Etv4 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for ETV4

Target: ETV4 (Ets Variant 4 (ETV4))

Alternative Name: Etv4

Background: Ets variant 4 (Etv4), also known as Pea3, is a member of the ETS family of transcription factors characterized by a conserved ETS DNA-binding domain that recognizes purine-rich sequences in target gene promoters. In zebrafish (Danio rerio), etv4 plays an essential role in embryonic development, particularly in processes regulated by fibroblast growth factor (FGF) signaling.

Etv4 functions as a key downstream effector of FGF signaling pathways, mediating transcriptional responses critical for tissue patterning and organogenesis. During zebrafish embryogenesis, etv4 is expressed in a variety of dynamic domains including the posterior mesoderm, developing somites, neural crest, and the pronephros. It acts in concert with other Pea3 subfamily members such as Etv5 to regulate genes involved in cell migration, proliferation, and differentiation.

Zebrafish etv4 has been extensively studied in the context of limb and fin development, neuromast formation, and branchial arch morphogenesis, making it a useful molecular marker for FGF activity and mesenchymal-epithelial interactions. Disruption of etv4 expression or function impairs normal developmental processes, underscoring its regulatory importance.

Due to its conserved function and regulated expression, zebrafish Etv4 serves as a valuable model for studying ETS transcription factors in vertebrate development and disease pathways, including cancer metastasis and skeletal disorders.

UniProt: Q9PUQ1