Beclin 1 antibody (AA 1-354)

Catalog No. ABIN7869243

The Mouse Monoclonal anti-Beclin 1 antibody is suitable to detect Beclin 1 in samples from Human, Mouse and Rat. It has been validated for WB, IF, FACS and IHC (p).

Quick Overview for Beclin 1 antibody (AA 1-354) (ABIN7869243)

Target: Beclin 1 (BECN1) (Beclin 1, Autophagy Related (BECN1))

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This Beclin 1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 2D12A3

Product Details anti-Beclin 1 Antibody

Binding Specificity: AA 1-354

Purpose: BECN1 Antibody / Beclin 1

Purification: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids M1-S354) was used as the immunogen for the BECN1 antibody.

Isotype: IgG1

Application Details

Application Notes: Optimal dilution of the BECN1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the BECN1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for Beclin 1

Target: Beclin 1 (BECN1) (Beclin 1, Autophagy Related (BECN1))

Alternative Name: BECN1

Background: Beclin-1, also known as also known as ATG6 or VPS30 is a protein that in humans is encoded by the BECN1 gene. Beclin-1 and its binding partner class III phosphoinositide 3-kinase (PI3K), also named Vps34, are required for the initiation of the formation of the autophagosome in autophagy. This gene participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration. Schizophrenia is associated with low levels of Beclin-1 in the hippocampus of the affected which causes diminished autophagywhich in turn results in increased neuronal cell death. It has been found that beclin-1 can promote autophagy in autophagy-defective yeast with a targeted disruption of apg6/vps30, and in human MCF7 breast carcinoma cells.

UniProt: Q14457

Pathways: Autophagy