NPY2R antibody (AA 1-367)

Catalog No. ABIN7869258

The Rabbit Polyclonal anti-NPY2R antibody is suitable to detect NPY2R in samples from Human. It has been validated for WB, ELISA, IF and ICC.

Quick Overview for NPY2R antibody (AA 1-367) (ABIN7869258)

Target: NPY2R (Neuropeptide Y Receptor Y2 (NPY2R))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NPY2R antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Product Details anti-NPY2R Antibody

Binding Specificity: AA 1-367

Purpose: NPY2R Antibody / Neuropeptide Y receptor type 2

Purification: Immunogen affinity purified

Immunogen: E.coli-derived human NPY2R recombinant protein (Position: M1-K367) was used as the immunogen for the NPY2R antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the NPY2R antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the NPY2R antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for NPY2R

Target: NPY2R (Neuropeptide Y Receptor Y2 (NPY2R))

Alternative Name: NPY2R

Background: NPY2R antibody detects Neuropeptide Y receptor type 2, a G protein-coupled receptor (GPCR) that mediates the effects of neuropeptide Y (NPY) and peptide YY (PYY) in regulating appetite, energy balance, and vascular tone. Encoded by the NPY2R gene on chromosome 4q31.3, this receptor belongs to the rhodopsin-like GPCR family and signals primarily through Gi/o proteins to inhibit adenylyl cyclase, reduce cyclic AMP production, and modulate calcium and potassium channel activity.

NPY2R is expressed in the central and peripheral nervous systems, particularly in hypothalamic nuclei involved in appetite control, as well as in adipose tissue, gastrointestinal tract, and cardiovascular system. Activation of NPY2R contributes to satiety signaling, vasoconstriction, and neuroendocrine secretion regulation. In neurons, NPY2R often acts as an autoreceptor, controlling presynaptic release of NPY and other neurotransmitters, thus fine-tuning synaptic transmission and energy homeostasis.

The NPY2R antibody is widely used in neuroscience, endocrinology, and metabolism research to investigate neuropeptide signaling, feeding behavior, and receptor pharmacology. Western blot analysis identifies a 43 kilodalton band corresponding to NPY2R, while immunohistochemistry reveals membrane-associated staining in hypothalamic neurons and vascular smooth muscle cells. This antibody supports studies examining receptor localization, ligand binding, and downstream signaling in physiological and pathological contexts.

At the molecular level, NPY2R activation influences pathways such as ERK1/2 and PI3K/AKT, affecting neuronal excitability and metabolic regulation. Altered NPY2R expression or function is linked to obesity, anxiety, hypertension, and gastrointestinal disorders. Pharmacological targeting of NPY2R offers therapeutic potential for appetite control and cardiovascular modulation. The NPY2R antibody provides a valuable tool for mapping receptor distribution and characterizing its role in neuroendocrine and metabolic signaling. NSJ Bioreagents validates this antibody for its applications, ensuring reproducible detection across neural and peripheral systems.

UniProt: P49146

Pathways: cAMP Metabolic Process, Synaptic Membrane, Feeding Behaviour