TMPRSS4 antibody (AA 1-369)

Catalog No. ABIN7869260

This Rabbit Polyclonal antibody specifically detects TMPRSS4 in WB, ELISA and FACS. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for TMPRSS4 antibody (AA 1-369) (ABIN7869260)

Target: TMPRSS4 (Transmembrane Protease, serine 4 (TMPRSS4))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TMPRSS4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Product Details anti-TMPRSS4 Antibody

Binding Specificity: AA 1-369

Purpose: TMPRSS4 Antibody / Transmembrane protease serine 4

Purification: Immunogen affinity purified

Immunogen: E.coli-derived human TMPRSS4 recombinant protein (Position: M1-K369) was used as the immunogen for the TMPRSS4 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the TMPRSS4 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the TMPRSS4 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for TMPRSS4

Target: TMPRSS4 (Transmembrane Protease, serine 4 (TMPRSS4))

Alternative Name: TMPRSS4

Background: TMPRSS4 antibody detects Transmembrane protease serine 4, a cell surface serine protease implicated in epithelial differentiation, tissue remodeling, and cancer progression. Encoded by the TMPRSS4 gene on chromosome 11q23.3, this enzyme belongs to the type II transmembrane serine protease family (TTSPs) characterized by an N-terminal transmembrane domain, a stem region, and a C-terminal trypsin-like serine protease domain. TMPRSS4 is synthesized as a zymogen that undergoes autocatalytic activation to generate the mature active enzyme at the plasma membrane.

TMPRSS4 is expressed in epithelial tissues of the gastrointestinal tract, lung, and kidney, as well as in certain tumors. It participates in the proteolytic activation of signaling molecules and extracellular matrix remodeling. Elevated TMPRSS4 expression has been linked to cancer invasion and metastasis through the activation of integrin and epithelial-mesenchymal transition pathways. TMPRSS4 promotes cell motility and survival by enhancing FAK and Src kinase signaling, modulating cytoskeletal organization, and upregulating matrix metalloproteinases.

The TMPRSS4 antibody is a critical reagent for cancer, developmental, and epithelial biology research. Western blot analysis typically identifies a 50-60 kilodalton band corresponding to the cleaved active form, while immunohistochemistry reveals membrane and cytoplasmic staining in epithelial cells and tumor tissues. The antibody allows detection of TMPRSS4 expression in normal and malignant tissues, aiding studies of protease-mediated signaling and tumor microenvironment remodeling.

Beyond oncology, TMPRSS4 may regulate viral entry for certain coronaviruses and influenza strains by cleaving viral envelope glycoproteins. Its involvement in epithelial homeostasis and infection response makes it an emerging therapeutic target. NSJ Bioreagents provides the TMPRSS4 antibody validated for its applications, ensuring robust and specific detection of this protease in diverse biological contexts.

UniProt: Q9NRS4