IFI44 antibody (AA 1-370)

Catalog No. ABIN7869263

This Rabbit Polyclonal antibody specifically detects IFI44 in WB, ELISA and FACS. It exhibits reactivity toward Mouse and Rat.

Quick Overview for IFI44 antibody (AA 1-370) (ABIN7869263)

Target: IFI44 (Interferon-Induced Protein 44 (IFI44))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IFI44 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Product Details anti-IFI44 Antibody

Binding Specificity: AA 1-370

Purpose: IFI44 Antibody / Interferon induced protein 44

Purification: Immunogen affinity purified

Immunogen: E.coli-derived mouse IFI44 recombinant protein (Position: M1-H370) was used as the immunogen for the IFI44 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the IFI44 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the IFI44 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for IFI44

Target: IFI44 (Interferon-Induced Protein 44 (IFI44))

Alternative Name: IFI44

Background: IFI44 antibody detects Interferon-induced protein 44, encoded by the IFI44 gene on chromosome 1p31.1. IFI44 antibody is commonly used in immunology, antiviral, and autoimmune disease research. IFI44 is an interferon-stimulated gene product induced by type I interferons and viral infection. It contributes to the host antiviral defense response and is a biomarker of interferon pathway activation.

Structurally, IFI44 is a ~50 kDa protein with coiled-coil domains but lacks known catalytic motifs. It localizes predominantly to the cytoplasm, with potential mitochondrial and cytoskeletal associations. Its structure suggests a role as a scaffold or regulator rather than an enzyme.

Functionally, IFI44 is strongly induced by viral infections including influenza, hepatitis C virus, and SARS-CoV. It enhances innate immune responses, possibly by modulating cytoskeletal dynamics or mitochondrial function. Researchers use IFI44 antibody to study interferon responses, viral pathogenesis, and autoimmune disease mechanisms.

Clinically, IFI44 is elevated in autoimmune diseases such as systemic lupus erythematosus and dermatomyositis, where interferon signatures correlate with disease severity. It has been proposed as a diagnostic biomarker for interferon-driven conditions. IFI44 polymorphisms may also influence susceptibility to viral infections. NSJ Bioreagents provides IFI44 antibody to support immunology and infectious disease research.

Experimentally, IFI44 antibody is used in western blotting to detect the ~50 kDa protein, in immunohistochemistry to assess tissue expression, and in immunofluorescence to study cytoplasmic distribution. Transcriptomic studies often pair IFI44 expression with IFI44L to define interferon response signatures, and IFI44 antibody provides the protein-level validation.

UniProt: Q8BV66