STYK1 antibody (AA 1-404)

Catalog No. ABIN7869322

The Rabbit Polyclonal anti-STYK1 antibody (ABIN7869322) specifically detects STYK1 in WB, ELISA, FACS, ICC and IF. The antibody is reactive with Human and Rat samples.

Quick Overview for STYK1 antibody (AA 1-404) (ABIN7869322)

Target: STYK1 (serine/threonine/tyrosine Kinase 1 (STYK1))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This STYK1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunofluorescence (IF)

Product Details anti-STYK1 Antibody

Binding Specificity: AA 1-404

Purpose: STYK1 Antibody / Serine/threonine/tyrosine kinase 1

Purification: Immunogen affinity purified

Immunogen: E.coli-derived human STYK1 recombinant protein (Position: M1-Y404) was used as the immunogen for the STYK1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the STYK1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the STYK1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for STYK1

Target: STYK1 (serine/threonine/tyrosine Kinase 1 (STYK1))

Alternative Name: STYK1

Background: STYK1 antibody detects Serine/threonine/tyrosine kinase 1, a membrane-associated receptor-like kinase implicated in cell growth, migration, and tumor progression. Encoded by the STYK1 gene on chromosome 12q24.13, this atypical kinase belongs to the receptor protein tyrosine kinase family but exhibits dual-specificity catalytic activity, phosphorylating both serine/threonine and tyrosine residues. STYK1 functions in intracellular signaling pathways that regulate proliferation, differentiation, and oncogenic transformation.

Structurally, STYK1 is composed of a short extracellular domain, a single transmembrane helix, and a cytoplasmic kinase domain that mediates signal transduction. Although structurally similar to receptor tyrosine kinases, it lacks a classical ligand-binding domain and likely operates through intracellular signaling or interaction with other membrane proteins. STYK1 activates downstream effectors, including the MAPK/ERK and PI3K/AKT pathways, promoting cell survival and motility.

The STYK1 antibody is widely used in cancer biology, kinase signaling, and molecular pathology research to investigate its oncogenic potential and functional roles in signal integration. Western blot analysis detects a 48 kilodalton band corresponding to STYK1, while immunohistochemistry shows strong membrane and cytoplasmic staining in epithelial tissues and cancer cells. This antibody provides a sensitive tool for evaluating kinase expression patterns and activation states in tumor and normal tissues.

Overexpression of STYK1 has been documented in lung, breast, prostate, and ovarian cancers, where it enhances tumor cell proliferation, metastasis, and resistance to apoptosis. It may function as a pseudokinase or a signaling scaffold that amplifies receptor-mediated responses. In normal physiology, STYK1 contributes to embryonic development and tissue regeneration by regulating kinase cross-talk. The STYK1 antibody enables researchers to dissect these mechanisms and explore its potential as a therapeutic target in oncology. NSJ Bioreagents validates this antibody for western blotting, immunohistochemistry, and immunofluorescence, ensuring high-quality and reproducible detection for kinase signaling research.

UniProt: Q6J9G0