SNX6 antibody (AA 1-406)

Catalog No. ABIN7869323

This Rabbit Polyclonal antibody specifically detects SNX6 in WB, ELISA, IF, IHC (p) and FACS. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for SNX6 antibody (AA 1-406) (ABIN7869323)

Target: SNX6 (Sorting Nexin 6 (SNX6))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SNX6 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Product Details anti-SNX6 Antibody

Binding Specificity: AA 1-406

Purpose: SNX6 Antibody / Sorting Nexin 6

Purification: Antigen affinity purified

Immunogen: Amino acids M1-T406 from the human protein were used as the immunogen for the SNX6 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the SNX6 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the SNX6 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for SNX6

Target: SNX6 (Sorting Nexin 6 (SNX6))

Alternative Name: SNX6

Background: SNX6 (Sorting Nexin 6) is a member of the sorting nexin family, a group of proteins that regulate intracellular trafficking and endosomal sorting. It contains a Phox (PX) domain that binds phosphoinositides, allowing SNX6 to associate with membranes of the endosomal system. Through its involvement in vesicular transport, SNX6 helps direct cargo proteins to specific cellular destinations. A SNX6 antibody is widely used in studies of endosomal trafficking, protein sorting, and membrane dynamics.

SNX6 is a component of the retromer complex, which mediates the retrograde transport of proteins from endosomes back to the trans-Golgi network. This pathway is crucial for maintaining receptor recycling, lysosomal enzyme trafficking, and signaling receptor turnover. By studying SNX6 with a SNX6 antibody, researchers can evaluate its role in cargo recognition and retromer function, as well as its contribution to cellular homeostasis.

Beyond vesicle trafficking, SNX6 has been implicated in multiple signaling pathways. It interacts with transforming growth factor beta (TGF-i²) receptors and may influence TGF-i² signaling, thereby linking endosomal sorting to cell growth and differentiation. Dysregulation of SNX6 expression or function has been associated with cancer progression, neurodegeneration, and viral infection. Employing a SNX6 antibody enables scientists to explore these diverse biological roles and to better understand how endosomal dynamics intersect with signaling networks.

NSJ Bioreagents offers a high-quality SNX6 antibody validated for applications including western blot, immunohistochemistry, and immunofluorescence. Choosing a SNX6 antibody from NSJ Bioreagents ensures reliable performance and reproducible results in studies of protein trafficking, retromer biology, and disease-related signaling.

UniProt: Q9UNH7

Pathways: EGFR Signaling Pathway