GFI1 antibody (AA 1-422)

Catalog No. ABIN7869342

The Rabbit Polyclonal anti-GFI1 antibody is suitable to detect GFI1 in samples from Human, Rat and Mouse. It has been validated for WB, ELISA, IHC (p) and FACS.

Quick Overview for GFI1 antibody (AA 1-422) (ABIN7869342)

Target: GFI1 (Growth Factor Independent 1 (GFI1))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GFI1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Product Details anti-GFI1 Antibody

Binding Specificity: AA 1-422

Purpose: GFI1 Antibody

Purification: Affinity purified

Immunogen: Recombinant human protein (amino acids M1-K422) was used as the immunogen for the GFI1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the GFI1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the GFI1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for GFI1

Target: GFI1 (Growth Factor Independent 1 (GFI1))

Alternative Name: GFI1

Background: Zinc finger protein Gfi-1 is a transcriptional repressor that in humans is encoded by the GFI1 gene. It is mapped to 1p22.1. This gene encodes a nuclear zinc finger protein that functions as a transcriptional repressor. This protein plays a role in diverse developmental contexts, including hematopoiesis and oncogenesis. It functions as part of a complex along with other cofactors to control histone modifications that lead to silencing of the target gene promoters. Mutations in this gene cause autosomal dominant severe congenital neutropenia, and also dominant nonimmune chronic idiopathic neutropenia of adults, which are heterogeneous hematopoietic disorders that cause predispositions to leukemias and infections. Multiple alternatively spliced variants, encoding the same protein, have been identified for this gene.

UniProt: Q99684