ILK antibody (AA 1-452)

Catalog No. ABIN7869382

The Mouse Monoclonal anti-ILK antibody (Clone 3C7E1) (ABIN7869382) specifically detects ILK in WB and IHC (p). The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for ILK antibody (AA 1-452) (ABIN7869382)

Target: ILK (Integrin-Linked Kinase (ILK))

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This ILK antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 3C7E1

Product Details anti-ILK Antibody

Binding Specificity: AA 1-452

Purpose: Integrin linked ILK Antibody / Integrin-linked kinase

Purification: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids M1-K452) was used as the immunogen for the Integrin linked ILK antibody.

Isotype: IgG2b

Application Details

Application Notes: Optimal dilution of the Integrin linked ILK antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Integrin linked ILK antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for ILK

Target: ILK (Integrin-Linked Kinase (ILK))

Alternative Name: Integrin linked ILK

Background: ILK, also known as Integrin-linked kinase, is a serine-threonine protein kinase. Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins. Integrin-linked kinase (ILK) interacts with the cytoplasmic domain of beta-1 integrin. This gene was initially described to encode a serine/ threonine protein kinase with 4 ankyrin-like repeats, which associates with the cytoplasmic domain of beta integrins and acts as a proximal receptor kinase regulating integrin-mediated signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. Recent results showed that ILK contains 5 ankyrin-like repeats, and that the C-terminal kinase domain is actually a pseudo-kinase with adaptor function.

UniProt: Q13418

Pathways: Regulation of Muscle Cell Differentiation, Regulation of Cell Size, Maintenance of Protein Location, Skeletal Muscle Fiber Development, Smooth Muscle Cell Migration