LMBR1L antibody (AA 1-489)

Catalog No. ABIN7869406

The Rabbit Polyclonal anti-LMBR1L antibody (ABIN7869406) specifically detects LMBR1L in WB, ELISA and FACS. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for LMBR1L antibody (AA 1-489) (ABIN7869406)

Target: LMBR1L (Limb Region 1 Like (LMBR1L))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LMBR1L antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Product Details anti-LMBR1L Antibody

Binding Specificity: AA 1-489

Purpose: LMBR1L Antibody / Limb region 1 like protein

Purification: Immunogen affinity purified

Immunogen: E.coli-derived human LMBR1L recombinant protein (Position: M1-Q489) was used as the immunogen for the LMBR1L antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the LMBR1L antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the LMBR1L antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for LMBR1L

Target: LMBR1L (Limb Region 1 Like (LMBR1L))

Alternative Name: LMBR1L

Background: LMBR1L antibody detects Limb region 1 like protein, encoded by the LMBR1L gene on chromosome 6q13. LMBR1L antibody is used to study this poorly characterized transmembrane protein, which is homologous to LMBR1. LMBR1L belongs to a family of proteins containing multiple transmembrane helices and putative sterol-sensing or lipid-binding domains. Although its precise biological function remains under investigation, LMBR1L is thought to contribute to membrane trafficking, vesicular transport, and immune regulation. Expression analyses demonstrate that LMBR1L is broadly expressed, with enrichment in hematopoietic tissues and immune cells.

Structurally, LMBR1L is predicted to contain 9 transmembrane segments and luminal loops that may bind sterols or interact with lipid-regulatory proteins. Its cytoplasmic regions contain motifs potentially involved in adaptor binding and vesicle sorting. Evolutionary conservation across vertebrates suggests an important but as yet undefined role. Related proteins such as LMBR1 are linked to limb development and Hedgehog signaling, raising interest in whether LMBR1L contributes to developmental or signaling pathways.

Functionally, emerging evidence implicates LMBR1L in immune regulation. Genome-wide association studies have associated polymorphisms in LMBR1L with autoimmune diseases, including systemic lupus erythematosus. Experimental knockdown in immune cells alters cytokine secretion and receptor trafficking, suggesting LMBR1L modulates signaling at the plasma membrane or endosomal compartments. Although mechanisms are not fully resolved, researchers use LMBR1L antibody to probe its localization, expression, and interactions in immune and developmental contexts.

Dysregulation of LMBR1L expression may contribute to disease susceptibility. Variants in LMBR1L have been associated with altered immune tolerance and increased risk of autoimmunity. Aberrant expression has also been observed in hematological malignancies, although its role in cancer biology requires further clarification. Understanding LMBR1L may provide new insights into membrane protein regulation, immunity, and human disease. NSJ Bioreagents provides LMBR1L antibody for researchers investigating this understudied membrane protein.

Experimentally, LMBR1L antibody is used in western blotting to detect the ~52 kDa protein, in flow cytometry to measure immune cell surface expression, and in immunohistochemistry to evaluate expression in tissues. Immunoprecipitation with LMBR1L antibody helps identify potential binding partners involved in vesicle trafficking. These approaches facilitate characterization of a protein whose function remains to be fully defined.

UniProt: Q6UX01