KLC1 antibody (Light Chain)

Catalog No. ABIN7869459

The Mouse Monoclonal anti-KLC1 antibody is suitable to detect KLC1 in samples from Human, Rat and Mouse. It has been validated for WB.

Quick Overview for KLC1 antibody (Light Chain) (ABIN7869459)

Target: KLC1 (Kinesin Light Chain 1 (KLC1))

Reactivity: Human, Rat, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This KLC1 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 4F2D7

Product Details anti-KLC1 Antibody

Binding Specificity: AA 1-537, Light Chain

Purpose: Kinesin light chain 1 Antibody / KLC1

Purification: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids M1-D537) was used as the immunogen for the Kinesin light chain 1 antibody.

Isotype: IgG2b

Application Details

Application Notes: Optimal dilution of the KLC1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the KLC1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for KLC1

Target: KLC1 (Kinesin Light Chain 1 (KLC1))

Alternative Name: Kinesin light chain 1

Background: Kinesin light chain 1 is a protein that in humans is encoded by the KLC1 gene. Conventional kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports various cargos along microtubules toward their plus ends. The heavy chains provide the motor activity, while the light chains bind to various cargos. This gene encodes a member of the kinesin light chain family. It associates with kinesin heavy chain through an N-terminal domain, and six tetratricopeptide repeat (TPR) motifs are thought to be involved in binding of cargos such as vesicles, mitochondria, and the Golgi complex. Thus, kinesin light chains function as adapter molecules and not motors per se. Although previously named kinesin 2, this gene is not a member of the kinesin-2 / kinesin heavy chain subfamily of kinesin motor proteins. Extensive alternative splicing produces isoforms with different C-termini that are proposed to bind to different cargos, however, the full-length nature and/or biological validity of most of these variants have not been determined.

UniProt: Q07866

Pathways: Ribonucleoprotein Complex Subunit Organization