MYB antibody (AA 1-590)

Catalog No. ABIN7869488

This Rabbit Polyclonal antibody specifically detects MYB in WB. It exhibits reactivity toward Zebrafish (Danio rerio).

Quick Overview for MYB antibody (AA 1-590) (ABIN7869488)

Target: MYB (V-Myb Myeloblastosis Viral Oncogene Homolog (Avian) (MYB))

Reactivity: Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MYB antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-MYB Antibody

Binding Specificity: AA 1-590

Purpose: Zebrafish c-Myb Antibody / Myb

Purification: Antigen affinity chromatography

Immunogen: E. coli-derived zebrafish C-myb recombinant protein (amino acids M1-I590) was used as the immunogen for the Zebrafish C-myb antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Optimal dilution of the Zebrafish C-myb antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Zebrafish C-myb antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for MYB

Target: MYB (V-Myb Myeloblastosis Viral Oncogene Homolog (Avian) (MYB))

Alternative Name: c-Myb

Background: C-Myb is a transcription factor that plays a critical role in the regulation of gene expression during the development and maintenance of hematopoietic stem and progenitor cells. In zebrafish, c-Myb is essential for the formation of definitive blood cells and is widely used as a marker of early hematopoiesis.

During zebrafish embryogenesis, c-Myb is expressed in the dorsal aorta, where hematopoietic stem cells first emerge, as well as in the developing thymus and other hematopoietic tissues. It regulates the expression of genes involved in cell proliferation, differentiation, and survival. Loss of c-Myb function leads to defects in blood cell development, particularly in the production of lymphoid and myeloid lineages.

Due to its conserved function in vertebrate hematopoiesis, zebrafish c-Myb is commonly used in research focused on blood development, leukemia, stem cell biology, and gene regulation. Its accessibility in zebrafish models allows for detailed in vivo studies of hematopoietic disorders and drug screening applications.

UniProt: F1QP25

Pathways: Chromatin Binding, Positive Regulation of Immune Effector Process