SP110 antibody (AA 1-615)

Catalog No. ABIN7869498

The Rabbit Polyclonal anti-SP110 antibody is suitable to detect SP110 in samples from Human, Mouse and Rat. It has been validated for WB, ELISA, IHC and FACS.

Quick Overview for SP110 antibody (AA 1-615) (ABIN7869498)

Target: SP110 (SP110 Nuclear Body Protein (SP110))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SP110 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)

Product Details anti-SP110 Antibody

Binding Specificity: AA 1-615

Purpose: SP110 Antibody / SP110 nuclear body protein

Purification: Immunogen affinity purified

Immunogen: E.coli-derived human SP110 recombinant protein (Position: M1-E615) was used as the immunogen for the SP110 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the SP110 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the SP110 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for SP110

Target: SP110 (SP110 Nuclear Body Protein (SP110))

Alternative Name: SP110

Background: SP110 antibody detects SP110 nuclear body protein, a transcriptional coactivator and nuclear body component involved in immune response regulation and chromatin organization. The UniProt recommended name is SP110 nuclear body protein (SP110). This nuclear protein functions as part of the promyelocytic leukemia (PML) nuclear body complex, participating in transcriptional control, apoptosis, and antiviral defense.

Functionally, SP110 antibody identifies a 688-amino-acid protein that acts as a coactivator for nuclear hormone receptors and NF-kappaB-dependent transcription. SP110 regulates gene expression in macrophages and lymphocytes, enhancing interferon-stimulated gene transcription and pathogen defense. It also contributes to chromatin remodeling and transcriptional repression of inflammatory genes through PML-associated nuclear bodies.

The SP110 gene is located on chromosome 2q37.1 and is highly expressed in hematopoietic tissues. SP110 expression is induced by interferon signaling and pathogen exposure, positioning it as a regulator of innate and adaptive immune responses. Its nuclear localization and coactivator activity support immune system homeostasis and pathogen resistance.

Pathologically, SP110 gene mutations are associated with hepatic veno-occlusive disease with immunodeficiency (VODI), a rare autosomal recessive disorder causing liver failure and impaired immunity. Abnormal expression of SP110 has also been linked to autoimmune conditions and susceptibility to intracellular infections such as tuberculosis. Research with SP110 antibody supports studies in nuclear organization, immune regulation, and transcriptional control.

SP110 antibody is suitable for western blotting, immunofluorescence, and immunohistochemistry to detect nuclear body components and transcriptional cofactors. NSJ Bioreagents offers SP110 antibody reagents validated for use in immunology, transcription, and chromatin regulation research.

Structurally, SP110 contains N-terminal SAND and coiled-coil domains that mediate DNA and protein binding, as well as nuclear localization signals that target it to PML bodies. This antibody enables analysis of SP110's role in transcriptional activation and immune regulation under interferon signaling conditions.

UniProt: Q9HB58