SEC61G antibody (AA 1-64)

Catalog No. ABIN7869509

This Rabbit Polyclonal antibody specifically detects SEC61G in ELISA, IHC and WB. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for SEC61G antibody (AA 1-64) (ABIN7869509)

Target: SEC61G (Sec61 gamma Subunit (SEC61G))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SEC61G antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Western Blotting (WB)

Product Details anti-SEC61G Antibody

Binding Specificity: AA 1-64

Purpose: SEC61G Antibody / Sec61 subunit gamma

Purification: Immunogen affinity purified

Immunogen: E.coli-derived human SEC61G recombinant protein (Position: M1-I64) was used as the immunogen for the SEC61G antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the SEC61G antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the SEC61G antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for SEC61G

Target: SEC61G (Sec61 gamma Subunit (SEC61G))

Alternative Name: SEC61G

Background: SEC61G antibody detects Protein transport protein Sec61 subunit gamma, encoded by the SEC61G gene on chromosome 7q21.11. SEC61G antibody is commonly used in studies of protein translocation, ER biology, and cancer. SEC61G is the gamma subunit of the Sec61 complex, the central protein-conducting channel of the endoplasmic reticulum (ER). This complex mediates cotranslational translocation of nascent polypeptides into the ER lumen or membrane, a process critical for secretory and membrane protein biosynthesis.

Structurally, SEC61G is a ~9 kDa integral membrane protein composed of a single transmembrane helix and short cytosolic and luminal tails. It functions as a stabilizing subunit of the heterotrimeric Sec61 channel, which also includes the alpha subunit SEC61A and the beta subunit SEC61B. SEC61G is embedded in ER membranes and contributes to complex stability and channel regulation.

Functionally, SEC61G supports protein translocation, integration of membrane proteins, and ER homeostasis. It helps maintain proper folding environments by coordinating with chaperones and quality control machinery. Loss of SEC61G destabilizes the Sec61 complex, impairing protein secretion and triggering ER stress responses. Researchers use SEC61G antibody to study secretory pathway biology, protein folding, and ER-associated degradation.

Clinically, SEC61G is implicated in cancer, where it is frequently amplified and overexpressed. Elevated SEC61G promotes survival and proliferation by supporting high rates of protein synthesis in tumor cells. It has been proposed as a prognostic marker and therapeutic target in glioblastoma and other malignancies. NSJ Bioreagents offers SEC61G antibody for research in protein secretion, cancer, and ER biology.

Experimentally, SEC61G antibody is applied in western blotting to detect the ~9 kDa protein, in immunofluorescence microscopy to study ER localization, and in immunohistochemistry to assess tumor expression. Co-immunoprecipitation with SEC61G antibody helps identify interactions with SEC61A, SEC61B, and chaperone partners.

UniProt: P60059