NBR1 antibody (AA 1-665)

Catalog No. ABIN7869519

The Rabbit Polyclonal anti-NBR1 antibody is suitable to detect NBR1 in samples from Human and Monkey. It has been validated for WB, ELISA, IF and FACS.

Quick Overview for NBR1 antibody (AA 1-665) (ABIN7869519)

Target: NBR1 (Neighbor of BRCA1 Gene 1 (NBR1))

Reactivity: Human, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NBR1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Flow Cytometry (FACS)

Product Details anti-NBR1 Antibody

Binding Specificity: AA 1-665

Purpose: NBR1 Antibody / Neighbor of BRCA1 gene 1 protein

Purification: Antigen affinity purified

Immunogen: E. coli-derived recombinant human protein (amino acids M1-H665) was used as the immunogen for the NBR1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the NBR1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the NBR1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for NBR1

Target: NBR1 (Neighbor of BRCA1 Gene 1 (NBR1))

Alternative Name: NBR1

Background: Neighbor of BRCA1 gene 1 protein is a protein that in humans is encoded by the NBR1 gene. The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled-coil motif, which is present in many genes with transformation potential. It functions as a specific autophagy receptor for the selective autophagic degradation of peroxisomes by forming intracellular inclusions with ubiquitylated autophagic substrates. This gene is located on a region of chromosome 17q21.1 that is in close proximity to the BRCA1 tumor suppressor gene. Alternative splicing of this gene results in multiple transcript variants.

UniProt: Q14596

Pathways: Autophagy