LIN7C antibody (AA 1-73)

Catalog No. ABIN7869540

The Rabbit Polyclonal anti-LIN7C antibody is suitable to detect LIN7C in samples from Human and Rat. It has been validated for WB, ELISA, IHC (p) and FACS.

Quick Overview for LIN7C antibody (AA 1-73) (ABIN7869540)

Target: LIN7C (Lin-7 Homolog C (LIN7C))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LIN7C antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Product Details anti-LIN7C Antibody

Binding Specificity: AA 1-73

Purpose: LIN7C Antibody / Protein lin-7 homolog C

Purification: Antigen affinity purified

Immunogen: An E.coli-derived human recombinant protein (amino acids M1-A73) was used as the immunogen for the LIN7C antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the LIN7C antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the LIN7C antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for LIN7C

Target: LIN7C (Lin-7 Homolog C (LIN7C))

Alternative Name: LIN7C

Background: Lin-7 homolog C is a protein that in humans is encoded by the LIN7C gene. LIN7C plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. It forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. LIN7C ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. It is also required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.

UniProt: Q9NUP9

Pathways: Synaptic Membrane