TMC6 antibody (AA 1-772)

Catalog No. ABIN7869552

The Rabbit Polyclonal anti-TMC6 antibody is suitable to detect TMC6 in samples from Human, Mouse and Rat. It has been validated for WB, ELISA, IHC, IF, FACS and ICC.

Quick Overview for TMC6 antibody (AA 1-772) (ABIN7869552)

Target: TMC6 (Transmembrane Channel-Like 6 (TMC6))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TMC6 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS), Immunocytochemistry (ICC)

Product Details anti-TMC6 Antibody

Binding Specificity: AA 1-772

Purpose: TMC6 Antibody / Transmembrane channel-like protein 6

Purification: Immunogen affinity purified

Immunogen: E.coli-derived human TMC6 recombinant protein (Position: M1-H772) was used as the immunogen for the TMC6 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the TMC6 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the TMC6 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for TMC6

Target: TMC6 (Transmembrane Channel-Like 6 (TMC6))

Alternative Name: TMC6

Background: The TMC6 antibody targets Transmembrane channel-like protein 6, a multipass membrane protein encoded by the TMC6 gene. Also known as EVER1, this protein is involved in zinc homeostasis and antiviral defense, particularly in epithelial and keratinocyte cells. Transmembrane channel-like protein 6 forms a complex with TMC8 (EVER2) to regulate intracellular zinc distribution, influencing transcriptional activity and immune responses. The TMC6 antibody provides a reliable reagent for studying epithelial immunity, metal ion regulation, and susceptibility to viral infection.

Transmembrane channel-like protein 6 is localized mainly to the endoplasmic reticulum and nuclear envelope, where it contributes to the regulation of zinc-dependent transcription factors. The TMC6 antibody supports localization and expression analyses that reveal how zinc flux affects keratinocyte differentiation and immune signaling. Through its partnership with TMC8, it restricts viral replication, particularly for human papillomaviruses (HPVs), by maintaining proper zinc balance within the nucleus.

Mutations in TMC6 cause Epidermodysplasia verruciformis (EV), a rare genodermatosis characterized by chronic HPV infection and increased skin cancer risk. The TMC6 antibody supports studies of this disease by enabling detection of protein loss or mislocalization in affected tissues. Lack of functional Transmembrane channel-like protein 6 disrupts zinc homeostasis, leading to impaired immune defense against HPV and uncontrolled keratinocyte proliferation. This discovery has highlighted TMC6 as a crucial host factor for viral resistance in epithelial tissues.

Beyond antiviral defense, Transmembrane channel-like protein 6 influences immune cell signaling and skin barrier function. The TMC6 antibody aids in quantifying these effects, revealing how altered zinc regulation impacts inflammation and epidermal differentiation. Its expression is highest in stratified epithelia but may also occur in immune cells and other tissues involved in zinc transport and immune surveillance.

The TMC6 antibody is validated for western blotting, immunohistochemistry, and immunofluorescence, providing distinct perinuclear staining consistent with endoplasmic reticulum localization. NSJ Bioreagents provides this antibody with validated specificity and performance for dermatological and immunological research. By supporting detailed examination of Transmembrane channel-like protein 6, the TMC6 antibody advances understanding of host defense, zinc metabolism, and mechanisms underlying susceptibility to viral infections and skin cancer.

UniProt: Q7Z403