USP5 antibody (AA 1-800)

Catalog No. ABIN7869566

This Rabbit Polyclonal antibody specifically detects USP5 in WB, ELISA, IF, IHC (p) and FACS. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for USP5 antibody (AA 1-800) (ABIN7869566)

Target: USP5 (Ubiquitin Specific Peptidase 5 (USP5))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This USP5 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Product Details anti-USP5 Antibody

Binding Specificity: AA 1-800

Purpose: USP5 Antibody / Ubiquitin carboxyl-terminal hydrolase 5

Purification: Antigen affinity purified

Immunogen: Amino acids M1-K800 from the human protein were used as the immunogen for the USP5 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the USP5 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the USP5 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for USP5

Target: USP5 (Ubiquitin Specific Peptidase 5 (USP5))

Alternative Name: USP5

Background: USP5 (Ubiquitin carboxyl-terminal hydrolase 5) is a member of the deubiquitinating enzyme (DUB) family, which plays a central role in regulating protein stability and turnover by processing ubiquitin chains. USP5 specifically disassembles unanchored polyubiquitin chains into monoubiquitin, maintaining a sufficient pool of free ubiquitin necessary for cellular homeostasis. A USP5 antibody is widely used to study protein degradation, ubiquitin recycling, and regulatory pathways involving the proteasome.

USP5, sometimes referred to as Isopeptidase T, functions in close connection with the ubiquitin-proteasome system, a critical mechanism for protein quality control. By hydrolyzing ubiquitin linkages, it prevents the accumulation of free polyubiquitin chains, which could otherwise interfere with proteasomal activity. Using a USP5 antibody enables researchers to evaluate its expression patterns, subcellular localization, and functional involvement in ubiquitin dynamics.

Dysregulation of USP5 has been linked to several disease processes. Elevated USP5 expression has been associated with tumor progression in cancers such as glioblastoma, colorectal cancer, and pancreatic cancer, where it contributes to cell proliferation and survival. It has also been implicated in neurological disorders due to its role in protein turnover, highlighting its importance in both health and disease. Investigating these roles with a USP5 antibody provides valuable insights into its potential as a biomarker or therapeutic target.

NSJ Bioreagents offers a high-quality USP5 antibody validated for applications including western blot, immunohistochemistry, and immunofluorescence. Selecting a USP5 antibody from NSJ Bioreagents ensures reliable results and reproducibility in studies focused on the ubiquitin-proteasome pathway, cancer biology, and protein regulation.

UniProt: P45974