TFF1 antibody (AA 1-84)

Catalog No. ABIN7869585

The Mouse Monoclonal anti-TFF1 antibody is suitable to detect TFF1 in samples from Human. It has been validated for IHC (p).

Quick Overview for TFF1 antibody (AA 1-84) (ABIN7869585)

Target: TFF1 (Trefoil Factor 1 (TFF1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TFF1 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: TFF1-7768

Product Details anti-TFF1 Antibody

Binding Specificity: AA 1-84

Purpose: Estrogen Inducible Protein pS2 Antibody / TFF1

Purification: Protein A/G affinity

Immunogen: A recombinant partial protein sequence (within amino acids 1-84) from the human protein was used as the immunogen for the Estrogen Inducible Protein pS2 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Estrogen Inducible Protein pS2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Estrogen Inducible Protein pS2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for TFF1

Target: TFF1 (Trefoil Factor 1 (TFF1))

Alternative Name: Estrogen Inducible Protein pS2

Background: It recognizes a polypeptide of 6.5 kDa, identified as pS2 estrogen-regulated protein. Its epitope is located in the c-terminus of human pS2 protein. pS2 is a trefoil peptide. Trefoil peptides are protease resistant molecules secreted throughout the gut that play a role in mucosal healing. These peptides contain three intra-chain disulfide bonds, forming the trefoil motif, or P-domain. pS2 is known to form dimers and this dimerization is thought to play a role in its protective and healing properties. About 60 % of breast carcinomas are positive for pS2. Staining is cytoplasmic, often with localization to the Golgi apparatus. pS2 is shown to be localized in normal stomach mucosa, gastric fluid, goblet cells in the colon and small intestine, and in ulcerations of the gastrointestinal tract. Several studies have shown that pS2 is primarily expressed in estrogen receptor-positive breast tumors and it may define a subset of estrogen-dependent tumors that displays an increased likelihood of response to endocrine therapy.

UniProt: P04155

Pathways: EGFR Signaling Pathway