Dynein Light Chain 1 (AA 1-89), (Light Chain) antibody

Catalog No. ABIN7869607

The Mouse Monoclonal anti-Dynein Light Chain 1 antibody (Clone 6G2H1) (ABIN7869607) specifically detects Dynein Light Chain 1 in WB, IF, FACS and IHC (p). The antibody is reactive with Mouse, Human and Rat samples.

Quick Overview for Dynein Light Chain 1 (AA 1-89), (Light Chain) antibody (ABIN7869607)

Target: Dynein Light Chain 1

Reactivity: Mouse, Human, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 6G2H1

Product Details

Binding Specificity: AA 1-89, Light Chain

Purpose: Dynein light chain 1 Antibody / DYNLL1

Purification: Affinity purified

Immunogen: Recombinant human protein (amino acids M1-G89) was used as the immunogen for the Dynein light chain 1 antibody.

Isotype: IgG2b

Application Details

Application Notes: Optimal dilution of the Dynein light chain 1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Dynein light chain 1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details

Target: Dynein Light Chain 1

Background: Dynein light chain 1, cytoplasmic is a protein that in humans is encoded by the DYNLL1 gene. Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. The protein described in this record is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity. Alternate transcriptional splice variants have been characterized.

UniProt: P63167