Recombinant Parvin, beta antibody (N-Term)

Catalog No. ABIN7869611

This Rabbit Monoclonal antibody specifically detects Parvin, beta in IHC (p). It exhibits reactivity toward Human.

Quick Overview for Recombinant Parvin, beta antibody (N-Term) (ABIN7869611)

Target: Parvin, beta (PARVB)

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Parvin, beta antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: PARVB-8214R

Product Details anti-Parvin, beta Antibody

Binding Specificity: AA 1-91, N-Term

Purpose: Beta-Parvin Antibody / PARVB (azide and preservative free)

Purification: Protein A/G affinity

Immunogen: The N-terminal region (residues 1-91) of the human protein was used as the immunogen for the Beta-Parvin antibody.

Isotype: IgG, kappa

Application Details

Application Notes: Optimal dilution of the Beta-Parvin antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: -20 °C

Storage Comment: Aliquot the Beta-Parvin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for Parvin, beta

Target: Parvin, beta (PARVB)

Alternative Name: Beta-Parvin

Background: Beta-parvin, also known as affixin, is a focal adhesion protein belonging to a family of ILKbinding proteins that contain tandem calponin homolog domains. Along with Alpha-parvin, Beta-parvin is one of the most widely researched and characterized members of this family. These two proteins interact with the ILK kinase domain in a way that is mutually exclusive and regulates both the activity of the kinase and actin cytoskeleton adhesion. Studies have shown Beta-parvin to be downregulated within human breast cancer cells, and that its expression may influence the progression of breast cancer (Johnstone, 2008). Additional research indicates a critical role for Beta-parvin in the regulation of cardiac contractility when it is in complex with ILK (Hannigan, 2007).

UniProt: Q9HBI1