TFPI2 antibody (AA 100-235)

Catalog No. ABIN7869769

The Mouse Monoclonal anti-TFPI2 antibody (Clone TFPI2-13025) (ABIN7869769) specifically detects TFPI2 in IHC (p). The antibody is reactive with Human samples.

Quick Overview for TFPI2 antibody (AA 100-235) (ABIN7869769)

Target: TFPI2 (Tissue Factor Pathway Inhibitor 2 (TFPI2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TFPI2 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: TFPI2-13025

Product Details anti-TFPI2 Antibody

Binding Specificity: AA 100-235

Purpose: TFPI2 Antibody / Tissue factor pathway inhibitor 2

Purification: Protein G affinity

Immunogen: A portion of amino acids 100-235 from human Tissue factor pathway inhibitor 2 protein was used as the immunogen for the TFPI2 antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the TFPI2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the TFPI2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for TFPI2

Target: TFPI2 (Tissue Factor Pathway Inhibitor 2 (TFPI2))

Alternative Name: TFPI2

Background: The extrinsic pathway of blood coagulation is initiated by contact of plasma factor VII with tissue factor, a cellular membrane glycoprotein that normally is segregated from the bloodstream but can be exposed after tissue injury or newly synthesized in endothelial cells or leukocytes after stimulation by endotoxin and cytokines. Inhibition of Factor VIIa tissue factor activity requires a plasma component (tissue factor pathway inhibitor (TFPI), lipoprotein-associated coagulation inhibitor (LACI) or extrinsic pathway inhibitor (EPI)) and factor Xa. TFPI directly inhibits factor Xa, and, in an Xa-dependent fashion, also inhibits the Factor VIIa tissue factor catalytic complex. TFPI is a multivalent, Kunitz-type proteinase inhibitor that circulates in association with plasma lipoproteins VLDL, LDL, and HDL. TFPI-2 (also known as placental protein 5) is a related glycoprotein that was originally isolated from human placenta.

UniProt: P48307